Sileo®: anxiety medication for dogs with noise phobia. Watch just how effective it is!

Video credit: Guthrie Pet Hospital

A sound solution to treat noise anxiety

Dexmedetomidine oromucosal gel, 0.1mg/mL

Sileo® (dexmedetomidine 0.1mg/mL) is an innovative, easy to use oromucosal gel for the alleviation of acute anxiety and fear associated with noise in dogs.

Easy to use and rapidly acting, Sileo® is a straightforward solution to a serious and under-diagnosed condition.

Serious: dogs in the grip of acute anxiety and fear may lose their sense of self altogether and self-harm, damage property, escape the property and get lost or run onto roads with terrible consequences. Trying to catch these pets may result in fear biting from a pet with no past history of aggression. In severe cases these pets are literally “out of their minds”.

Under-diagnosed: acute noise anxiety is immediate but often short lasting. Your client rarely makes these episodes the subject of a veterinary visit, or remembers to discuss the issue during a visit. But clients are usually shattered at home when the dog exhibits symptoms of acute fear and anxiety during fireworks, construction, parties, storms, roadworks, firearms use, mining and other trigger stimuli.  Only you, their veterinarian can begin a conversation about acute noise anxiety and the results are clear – when the subject is raised up to 50% of owners will admit significant problems with behaviours around acute noise triggers in their pet.

Truly Treatable - For The First Time.

Sileo® is a medicinal intervention to break the response cycle in the face of the noise stimulus.  Sileo® can be used to manage symptoms and turn the “vicious cycle” of noise anxiety in favour of the veterinarian, the pet and the owner.

Behavioural training can be difficult to impossible as these pets are already sensitised and have a predictable, if destructive, response.  Sileo® breaks the cycle by managing trigger based behaviour and opening the door for behavioural training.

Product Information

Product Description
• Especially developed for dogs who suffer from acute anxiety and fear associated with noise.

• Presented as a green gel in a special “Dial the dose”syringe.

• Syringes packed in Australia’s first child resistant carton for easy storage in blocks of 1,3,5 1- or 20 pre-filled syringes.

• Easy storage at 25C or less (Air Conditioning).

• Opened syringes can be re-capped and stored in original packaging as above for up to 4 weeks.

Used just before or right at the time of the triggering noise/anxiety stimulus, Sileo® immediately controls distressing and potentially destructive behaviours, resulting in less stress for the dog and the owner.

Easy to use gel and good shelf life after opening maximises value for money.

Convenient administration into the cheek pouch makes dosing easy and minimises the risk of accidental biting even in frightened dogs.

Easy “dot-based” dosing measure means no difficult dosing calculations, and a rapid effect for maximum behaviour control.

“Dial the dose” syringe makes it easy for clients to administer a correct dose.

Non-residual – can be dosed more than once during a single triggering event.

High margin of safety allows for redosing after 2 hours with high safety margin.

Syringe cannot unlock accidentally – the dose the client dials is the dose that is delivered.

Child resistant cardboard packaging maximises child safety and minimises accidental dosing.

Signs of Anxiety
Signs of anxiety include but are not limited to: Cowering, ears back, hiding, hyper-vigilance, lip licking, owner seeking, pacing and restlessness, panting, refusing to eat, trembling, vocalising, yawning.

Most treatments for acute noise based anxiety have little effect. Punishment is ineffective and inappropriate, and praise for “brave” behaviour may not be strong enough to overcome the triggers, particularly because most of these animals will not take treats. Pheromones, essential oils and body wraps may assist but are unlikely to be completely effective.

Sileo® has the advantage of being able to be used at or even 30-60 mind BEFORE the first sign of anxiety, works rapidly, and can be redosed according to label if the trigger persists.

See "Signs of Anxiety" poster download.
Mode of Action
Dexmedetomidine is a powerful, potent and selective alpha2-adrenergic agonist that has been traditionally used in veterinary medicine as an injectable for heavy sedation and anaesthesia in a complex dosing system based on body surface area.

It is minimally absorbed in the gastrointestinal tract, BUT with the right formulation can be well-absorbed through the buccal mucosa.

It has been discovered that at low doses, given into the buccal pouch in dogs, there is a definite and well defined anxiolytic effect without heavy sedation and no anaesthesia. It is this activity that makes Sileo® so useful for the control of noise triggered behaviours in dogs.

The anxiolytic effect is mediated through the brainstem, where dexmedetomidine binds with the pre-synaptic alpha2-receptors in the locus coeruleus, preventing or reducing the release of noradrenaline. Lower levels of noradrenaline reduce the physiological and behavioural manifestation of stress fear and anxiety.

The gel formulation helps contain the medicine in the buccal pouch and presents the medication to the mucosa for absorption most efficiently. The user-friendly administration method maximises correct deposition of gel into the buccal pouch with minimal risk to owners.

Contraindications, Precautions and Side Effects

Precautions: use with care in cases of dogs with:

- pre-existing hypotension, bradycardia, or hypoxia

- currently using other CNS depressants

- dogs less than 6-week-old (the product is untested in this group)

- dogs with dental or gingival disease (may affect absorption)

- pregnant bitches (may induce uterine contractions or decrease foetal blood pressure)

- lactating bitches (untested in this group)

Contraindications: DO NOT USE SILEO® IN:

- severe cardiovascular, respiratory, liver or kidney disease states

- shock, severe debilitation or stress eg due to extreme heat, cold or fatigue

- dogs with hypersensitivity to dexmedetomidine or any of the excipients - dogs obviously sedated from previous dosing

Overdose: Symptoms may include:

- Sedation is the most common symptom, with the severity and duration dose-dependent. If sedation occurs, keep the dog warm.

- reduced blood pressure, heart rate, respiratory rate and body temperature

- mydriasis,

- depression of motor and secretory GIT function

- temporary AV Block

- diuresis

- hypoglycaemia

Antidote: alpha2 adrenoceptor antagonists are antidotal, eg Atipamezole.

How to use

Indications for use:

All directions for use can be found on the label, and you should read the label before use.  



Dose Rate:

Sileo® is administered onto the oral mucosa between the dog’s cheek and gum at the dose of 125 mcg/m2.

The gel is absorbed through the oral mucosa and therefore it should NOT be swallowed. If the gel is swallowed, the product may not be effective. If the gel is swallowed, do not repeat the dose for at least two hours.

The following table provides the acceptable dosage for each weight range. Each dot (●) represents 0.25 mL of Sileo®. Each ml contains the equivalent to 0.1mg dexmedetomidine hydrochloride.

Table 1. Dosage by body weight:

This is an example showing Sileo® used for dogs scared of fireworks:

Video credit: Boca Midtowne Animal Hospital

Registered pursuant to the ACVM Act 1997 No. A011456. See for registration conditions.

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